Ozempic vs Wegovy: What’s the Difference and Which One Works for You?

When people talk about Ozempic, a once-weekly injectable medication originally approved for type 2 diabetes. Also known as semaglutide, it has become one of the most talked-about drugs in weight loss and metabolic health. Many don’t realize that Wegovy, the same active ingredient as Ozempic but approved specifically for chronic weight management. Also known as semaglutide for obesity, it’s not just a repackaged version—it’s dosed differently and designed for a different goal. Both are GLP-1 receptor agonists, meaning they slow digestion, reduce appetite, and help your body regulate blood sugar. But that’s where the similarities end.

Here’s the simple truth: Ozempic is FDA-approved for treating type 2 diabetes, with a typical dose of 0.5 mg or 1 mg once a week. Wegovy, a higher-dose version of the same molecule, approved only for weight loss in adults with obesity or overweight with at least one weight-related condition. Also known as semaglutide 2.4 mg, it’s prescribed at 2.4 mg weekly—the highest dose available for this class of drugs. That’s why Wegovy tends to produce more weight loss in clinical trials—around 15% of body weight on average—while Ozempic users typically lose 5-10%. But Ozempic is often cheaper, especially if you’re using it for diabetes and your insurance covers it. Walmart and some pharmacies now sell generic semaglutide for under $90 a month, making it a practical option for many.

Insurance often denies coverage for Wegovy because it’s labeled as a weight loss drug, not a medical necessity. Ozempic, on the other hand, is more likely to be approved if you have diabetes. But if you’re not diabetic and just want to lose weight, Wegovy is the only one legally approved for that purpose. Some doctors prescribe Ozempic off-label for weight loss, but that’s not always covered. The side effects are similar—nausea, vomiting, diarrhea—but they tend to be stronger with Wegovy because of the higher dose. If you’re trying to decide, ask yourself: Are you managing blood sugar, or are you trying to shed excess weight? That’s the real question.

You’ll find posts here that break down how these drugs compare to metformin, what they cost at pharmacies, and whether insurance will cover them. You’ll also see how semaglutide fits into broader conversations about diabetes treatment, metabolic health after 50, and the real science behind weight loss medications. Some people swear by them. Others can’t tolerate the side effects. This collection gives you the facts—not the hype—so you can decide what’s right for your body.